What is Livmarli (maralixibat) for?
Buy Livmarli (maralixibat). Livmarli (maralixibat) is a treatment for itching in patients with Alagille syndrome (ALGS) aged 1 and up. It works by blocking the ileal bile acid transporter (IBAT).
It comes as an oral solution with 9.5 mg/30 ml of maralixibat.
How does Livmarli (maralixibat) work?
ALGS is a rare genetic condition that affects the bile ducts. This leads to a buildup of bile acids in the liver, causing inflammation and damage. It also stops the liver from removing waste from the blood.
Patients often have severe itching, but the exact cause is not fully understood.
Maralixibat, the main ingredient in Livmarli, blocks the ileal bile acid transporter (IBAT). This increases the amount of bile acids in the feces. It helps reduce the buildup of bile acids in the blood and liver, which can cause itching and damage.
Where has Livmarli (maralixibat) been approved?
Livmarli (maralixibat) is approved for treating itching in ALGS patients by:
- The Food and Drug Administration (FDA), USA on September 29, 2021.
The manufacturer also got a rare pediatric disease priority review voucher.
This medicine might be approved in other places too. If you have questions, contact our support team.
How is Livmarli (maralixibat) taken?
The usual dose is:
- Start with 190 mcg/kg body weight orally once a day, 30 minutes before your first meal.
- After a week, increase to 380 mcg/kg orally once a day if it’s okay.
For those over 70 kg, the maximum dose is 3 mL or 28.5 mg daily.
If you miss a dose, take it as soon as you remember within 12 hours. Then, take your next dose at the usual time. If it’s more than 12 hours, skip the missed dose and take the next one at the usual time.
Take certain high cholesterol medicines like cholestyramine, colesevelam, or colestipol at least 4 hours before or after Livmarli. Check with your doctor if you’re unsure.
Your Livmarli dose might need to change or stop if your liver tests show problems.
For more details on dosage and how to take Livmarli, see the official prescribing information in our references section.
Note: Always talk to your doctor for personalized advice on taking Livmarli.
Are there any known adverse reactions or side effects of Livmarli (maralixibat)?
Common adverse reactions
The most common side effects (≥5% of patients) include:
- Diarrhea
- Belly (abdominal pain)
- Vomiting
- Fat-soluble vitamin deficiency
- Changes in liver tests
- Stomach and intestinal (gastrointestinal) problems, including gastrointestinal bleeding
- Bone fractures
Serious adverse reactions
The serious side effects listed include:
- Serious liver injury
Use in a specific population
It’s not clear if Livmarli (maralixibat) is safe for unborn babies or if it gets into breast milk. If you’re pregnant or planning to be, talk to your doctor. They can help with feeding your baby while you’re taking this medicine.
For a full list of side effects and reactions, check the official prescribing information.