What is Palynziq (pegvaliase-pqpz) for?
Buy Palynziq (pegvaliase-pqpz). Palynziq (pegvaliase-pqpz) is a treatment for adults and teens with PKU. It helps control blood phenylalanine levels. It comes in three doses: 2.5 mg, 10 mg, and 20 mg.
How does Palynziq (pegvaliase-pqpz) work?
Palynziq (pegvaliase-pqpz) changes phenylalanine into ammonia and trans-cinnamic acid.
It helps patients with PKU by reducing blood phenylalanine levels. This is because it replaces the missing PAH enzyme.
Where has Palynziq (pegvaliase-pqpz) been approved?
Palynziq (pegvaliase-pqpz) has been approved in several places:
- The Food and Drug Administration (FDA), USA, approved it on May 24, 2018. It’s for adults with PKU who can’t control their blood phenylalanine levels.
- The European Medicines Agency (EMA), European Union (EU), approved it on May 03, 2019. It’s for patients aged 16 and older with PKU who can’t control their blood phenylalanine levels.
This medicine might also be approved in other places. If you have questions, contact our support team.
How is Palynziq (pegvaliase-pqpz) taken?
Doctors should guide the use of Palynziq (pegvaliase-pqpz). The dosage has several phases. Here’s how it works:
Posology
First, a blood test is needed to start treatment. Blood tests should be done monthly.
Patients should keep their diet consistent until they find the right dose.
Dosing regimens
Induction
Start with 2.5 mg of Palynziq (pegvaliase-pqpz) once a week for 4 weeks.
Titration
Gradually increase the dose based on how well the patient can tolerate it. Aim for a daily dose that keeps blood phenylalanine levels in check.
Maintenance
The right dose is based on the patient’s blood phenylalanine levels and how well they can handle the treatment. It also depends on their diet.
Special populations might need different doses. If side effects or symptoms worsen, the dose might need to be lowered.
For more details on Palynziq (pegvaliase-pqpz) dosage and how to take it, see the official prescribing information. It includes a table with the recommended dosing regimen.
Note: Always talk to your doctor about the right dose for you and any possible drug interactions.
Are there any known side effects or adverse reactions of Palynziq (pegvaliase-pqpz)?
Common adverse reactions
The most common side effects include:
- injection site reactions
- arthralgia
- hypersensitivity reactions
- headache
- generalized skin reactions lasting at least 14 days
- pruritus
- nausea.
Serious adverse reactions
The most common serious side effects include:
- anaphylaxis
- other hypersensitivity reactions.
Use in specific populations
There’s not enough data on Palynziq use in pregnant women. But, high levels of phenylalanine can harm the fetus. This includes risks like miscarriage and birth defects.
Palynziq is not tested in kids under 16. The data for 16 to 18-year-olds is in the official info. There are no studies on people over 65.