What is Skilarence (dimethyl fumarate)?
Buy Skilarence (dimethyl fumarate). Skilarence (dimethyl fumarate) is a treatment for psoriasis. It also helps with multiple sclerosis.Skilarence belongs to a class of medications known as fumaric acid esters. It works by modulating the body’s immune response, reducing inflammation, and slowing down the excessive growth of skin cells that is characteristic of psoriasis. Skilarence is available in the form of delayed-release tablets that are usually taken orally once or twice a day, as directed by a healthcare provider.
Who is Skilarence (dimethyl fumarate) for?
It’s for people with severe plaque psoriasis. It works when skin treatments don’t help enough.
How does Skilarence (dimethyl fumarate) work?
Psoriasis makes the immune system attack its own cells. Dimethyl fumarate in Skilarence reduces T cells. This stops inflammation and psoriasis.
Where has Skilarence (dimethyl fumarate) been approved?
It’s approved for psoriasis in the European Union. This was on June 23, 2017.
- European Medical Agency (EMA), European Union, June 23, 2017.
This medicine might be approved in other places too. If you have questions, contact our support team.
How is Skilarence (dimethyl fumarate) taken?
Start with a low dose and increase it slowly.
The usual dose is:
- Week 1: 30 mg (1 30 mg tablet) once daily
- Week 2: 30 mg (1 30 mg tablet) twice daily (1 tablet in the morning and 1 in the evening).
- Week 3: 30 mg (1 30 mg tablet) 3 times daily (1 tablet in the morning, 1 at midday and 1 in the evening).
- Week 4: 120 mg daily ( 1 120 mg tablet) once daily (in the evening)
- Week 5: 120 mg (1 120 mg tablet) twice daily (1 tablet in the morning and 1 in the evening).
- Week 6: 120 mg (1 120 mg tablet) 3 times daily (1 tablet in the morning, 1 at midday and 1 in the evening).
- Week 7: 120 mg (1 120 mg tablet) twice per day ( 1 tablet in the morning and 1 tablet at midday), and 240 mg (2 120 mg tablets) once per day (2 tablets in the evening)
- Week 8: 240 mg (2 120 mg tablets) twice per day ( 1 tablet in the morning and 1 tablet in the evening), and 120 mg (1 120 mg tablet) once per day (1 tablets at midday)
- Week 9+: 240 mg (2 120 mg tablets) 3 times per day (2 tablets in the morning, 2 at midday and 2 in the evening).
If a dose increase is hard to take, you can go back to the last dose you could handle.
If your skin gets better before reaching the highest dose, you don’t need to increase it. After your skin improves, you can start to lower your dose. This helps you keep the benefits without taking too much.
Warning: Skilarence (dimethyl fumarate) might reduce the number of white blood cell and thus facilitate infections.
For full details on Skilarence (dimethyl fumarate) dosage and how to take it, see the official prescribing information. It’s in our references section.
Note: Please consult with your treating doctor for personalised dosing.
Are there any known side effects or adverse reactions of Skilarence (dimethyl fumarate)?
Common adverse reactions
The most common side effects include:
- changes in blood counts: lymphopenia, leukopenia, eosinophilia, leukocytosis
- decreased appetite
- headache
- paresthesia (an abnormal sensation, typically tingling or pricking)
- gastrointestinal disorders (diarrhoea, abdominal distension, abdominal pain, nausea, vomiting, dyspepsia, constipation, abdominal discomfort, flatulence
- skin and subcutaneous tissue disorders (erythema, skin burning sensation, pruritus)
- general disorders (fatigue, feeling hot, asthenia)
- increased hepatic (liver) enzymes.
Serious adverse reactions
The serious side effects include:
- acute lymphatic leukaemia (very rare)
- pancytopenia (deficiency of all three cellular components of the blood) (very rare)
- infections
Use in specific populations
Skilarence (dimethyl fumarate) can be fatal for a fetus. It is advised to avoid pregnancies and breastfeeding.