What is Livdelzi (seladelpar) for?
Livdelzi (seladelpar) is used to treat primary biliary cholangitis (PBC) in adults. It works well with ursodeoxycholic acid (UDCA) for those who don’t respond well to UDCA. It’s also an option for those who can’t take UDCA.
Livdelzi (seladelpar) comes in capsules, each containing 10 mg.
How does Livdelzi (seladelpar) work?
Livdelzi (seladelpar) activates a protein called PPAR-delta (δ). This may help lower bile acid production. But how it helps PBC patients is still a bit of a mystery.
Studies show it reduces bile acid levels. This happens by decreasing an enzyme called CYP7A1. It does this through a protein called FGF21.
Where has Livdelzi (seladelpar) been approved?
Livdelzi (seladelpar) is approved by the FDA in the USA.
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