What is Rezurock (belumosudil) for?
Rezurock (belumosudil) is a medicine for adults and kids 12 and older. It helps those with chronic graft-versus-host disease (cGVHD). This disease happens after two other treatments have failed.
It comes in tablet form, with 200 mg belumosudil in each tablet.
How does Rezurock (belumosudil) work?
In cGVHD, immune cells from the transplant attack the patient’s cells. This leads to inflammation and fibrosis. Fibrosis is like a wound-healing process but can harm joints or skin in cGVHD.
It can also cause serious breathing problems if it affects the lungs.2,3
The main ingredient in Rezurock, belumosudil, blocks a protein called ROCK2. ROCK is involved in inflammation and fibrosis.
By stopping ROCK2, Rezurock may prevent and reduce fibrosis in cGVHD.
Where has Rezurock (belumosudil) been approved?
Rezurock (belumosudil) was approved for cGVHD treatment by:
- The Food and Drug Administration (FDA), USA on July 16, 2021.
It was approved quickly and was given a special status by the FDA. The FDA reviewed it under a new program.
This medicine might also be approved in other places. If you have questions, contact our support team.
How is Rezurock (belumosudil) taken?
The usual dose is:
- 200 mg taken orally once a day with food.
During treatment, blood tests should be done at least monthly.
If side effects happen, the doctor might lower the dose.
When taken with certain medicines, the dose should be 200 mg twice daily.
For more details on dosage and how to take it, see the official prescribing information.
Note: Always talk to your doctor about the right dose for you.
Are there any known adverse reactions or side effects of Rezurock (belumosudil)?
Common adverse reactions
The most common side effects ( ≥20% of patients) include:
- infections
- tiredness or weakness
- nausea
- diarrhea
- shortness of breath
- cough
- swelling
- bleeding
- stomach (abdominal) pain
- muscle or bone pain
- headache
- high blood pressure
Use in a specific population
Rezurock (belumosudil) can be dangerous for a fetus. It’s best to avoid pregnancy and breastfeeding. People who can get pregnant should use birth control during treatment.
For a full list of side effects, see the official prescribing information.
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