What is Tarpeyo (budesonide) for?
Tarpeyo (budesonide) is a medicine for adults with a kidney disease called IgAN. It helps by reducing protein in the urine. This is for those at risk of fast disease progress, with a urine protein-to-creatinine ratio of at least 1.5g/g.
It comes in capsule form, each with 4 mg budesonide.
How does Tarpeyo (budesonide) work?
IgAN, or Berger’s disease, is a rare kidney disease. It happens when IgA antibodies build up in the kidneys. This causes inflammation and damage.
The active ingredient in Tarpeyo, budesonide, is a corticosteroid. It works on B cells in the small intestines. By stopping B cells from growing and working too much, Tarpeyo reduces IgA and kidney damage.
Where has Tarpeyo (budesonide) been approved?
Tarpeyo (budesonide) was approved for IgAN treatment by:
- The Food and Drug Administration (FDA), USA on December 17, 2021.
It was approved under Accelerated Approval. It also got Orphan Drug designation for rare diseases.
This medicine might be approved in other places too. If you have questions, contact our support team.
How is Tarpeyo (budesonide) taken?
The standard dosage is:
- 16 mg (four capsules of 4 mg) taken orally once a day, in the morning at least 1 hour before a meal.
Treatment lasts 9 months. When stopping, take 8 mg (two capsules) once a day for the last two weeks.
Swallow the capsules whole. Do not open, crush, or chew them.
For more details on dosage and use, see the official prescribing information in our references section.
Note: Always talk to your doctor for personalized advice on dosage.
Are there any known adverse reactions or side effects of Tarpeyo (budesonide)?
Common adverse reactions
The most common side effects (53% of patients) include:
- High blood pressure (hypertension)
- Swelling of your lower legs or hands (peripheral edema)
- Muscle spasms
- Acne
- Skin irritation (dermatitis)
- Weight increase
- Shortness of breath (dyspnea)
- Face edema
- Indigestion (dyspepsia)
- Tiredness (fatigue)
- Thicker or more hair on your body and face (hirsutism)
Serious adverse reactions
The serious side effects include:
- Having too much cortisol in your body (hypercorticism)
- Not able to produce enough cortisol (adrenal suppression)
- Weakening of your immune system
- Serious hypersensitivity reactions
Use in a specific population
Studies show Tarpeyo (budesonide) is safe for pregnant women. It’s not clear if it goes into breast milk. Always talk to your doctor about any risks.
People with serious liver issues might face more side effects.
For a full list of side effects and reactions, see the official prescribing information.
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