What is Vocabria (cabotegravir) for?
Vocabria (cabotegravir) is a medicine for adults with HIV-1 infection. It’s used with another medicine called rilpivirine. This is for people already on antiretroviral medicines.
It comes in a vial of cabotegravir suspension and a vial of rilpivirine suspension. The options are 400/600mg or 600/900mg.
How does Vocabria (cabotegravir) work?
The main ingredient, cabotegravir, blocks an enzyme called integrase. This enzyme is used by the virus to multiply. By stopping integrase, cabotegravir reduces HIV particles in the blood.
This medicine can’t cure HIV or AIDS. But it helps the immune system recover and prevents more damage.
Where has Vocabria (cabotegravir) been approved?
Vocabria (cabotegravir) has been approved in several places:
- Health Canada on September 23, 2020.
- European Medicines Agency (EMA) on December 17, 2020.
- The Food and Drug Administration (FDA), USA on January 21, 2021.
- Therapeutic Goods Administration (TGA), Australia on February 10, 2021.
This medicine might also be approved in other areas. If you have questions, contact our support team.
How is Vocabria (cabotegravir) taken?
The usual dose is:
- One 30-mg tablet of Vocabria (cabotegravir) with one 25-mg tablet of Edurant (rilpivirine) daily for a month.
- Then, Vocabria and rilpivirine injections are given monthly or every 2 months. The first injections are on the same day as the last tablet dose.
Tablets can be taken with or without food.
Vocabria (cabotegravir) might affect other medicines. Other medicines could also change how it works. Always tell your doctor about all medicines you’re taking.
Warning: Don’t use Vocabria (cabotegravir) with carbamazepine, oxcarbazepine, phenobarbital, phenytoin, or rifampicin, rifapentine. These can make Vocabria less effective.
For more details on dosage and how to take Vocabria (cabotegravir), see the official prescribing information. We have it listed in our references section.
Note: Always talk to your doctor for the right dosage for you.
Are there any known adverse reactions or side effects of Vocabria (cabotegravir)?
Common adverse reactions
The most common side effects are:
- Headache
- Nausea
- Abnormal dreams
- Anxiety
- Insomnia
Serious adverse reactions
Here are the serious side effects:
- Allergic reactions
- Liver problems
- Depression or mood changes
Use in a specific population
It is not known if Vocabria (cabotegravir) can harm a fetus. Tell your doctor if you are pregnant or plan to become pregnant or are breast-feeding.
Mothers with a HIV-1 infection should not breastfeed. The virus can pass to the baby via the breast milk. It is not known if the medicine can pass on to the baby via breast milk and harm a fetus.
For a comprehensive list of side effects and adverse reactions, please refer to the official prescribing information.
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